Article

Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

2021-10-23

Abstract excerpt

Tumor dependency on specific metabolic signals has guided numerous therapeutic approaches. Here we identify melanoma addiction to the mitochondrial protein Glutaryl-CoA dehydrogenase (GCDH), a component in lysine metabolism which controls protein glutarylation. GCDH knockdown promoted apoptotic Unfolded Protein Response signaling and cell death in melanoma cells, an activity blocked by knockdown of the upstream ly...

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Literature Corpus work: ceecc1d2-de85-5ad6-b878-d6a69fb256c5
DOI: 10.1101/2021.10.22.465495

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