Dysfunction of an energy sensor NFE2L1 triggers uncontrollable AMPK signal and glucose metabolism reprogramming

Abstract excerpt

NFE2L1 (also called Nrf1) acts a core regulator of redox signaling and metabolism homeostasis, and thus its dysfunction results in multiple systemic metabolic diseases. However, the molecular mechanism(s) by which NFE2L1 regulates glycose and lipid metabolism is still elusive. Here, we found that the loss of NFE2L1 in human HepG2 cells led to a lethal phenotype upon glucose deprivation. The uptake of glucose was a...

Topics

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• Carcinogenesis
• Cell Line, Tumor
• Gene Expression Regulation, Neoplastic
• Mutation
• Neoplasms
• NF-E2-Related Factor 2
• Oxidative Stress
• Reactive Oxygen Species

Identifiers and source

Literature Corpus work

72ee5ffa-c95e-5acd-bfaf-ac627618bce7

DOI

10.1101/2021.09.07.459348