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XRCC4 glutarylation increases sensitivity to PARP inhibitors in breast cancer by inhibiting mTOR activity and promoting autophagy

2026-06-08

Abstract excerpt

<title>Abstract</title> <p> Background Glutarylation, a newly identified form of protein acylation, has been linked to the regulation of tumor metabolism. However, the role of glutarylation in breast cancer is currently unclear. Methods Multi-omics datasets analysis was employed to delineate the characteristics of XRCC4 in breast cancer. The roles of XRCC4 in breast cancer were validated using CCK-8, EdU, and...

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Literature Corpus work
e4967b03-4d95-540f-a251-1f24740337c6
DOI
10.21203/rs.3.rs-9924119/v1
Open publication

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XRCC4 glutarylation increases sensitivity to PARP inhibitors in breast cancer by inhibiting mTOR activity and promoting autophagyDOI 10.21203/rs.3.rs-9924119/v1
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