Article
Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.
Molecular cell - 16 Jun 2016
Riscal Romain, Schrepfer Emilie, Arena Giuseppe, Cissé Madi Y, Bellvert Floriant, Heuillet Maud, Rambow Florian, Bonneil Eric, Sabourdy Frédérique, Vincent Charles, Ait-Arsa Imade, Levade Thierry, Thibaut Pierre, Marine Jean-Christophe, Portais Jean-Charles, Sarry Jean-Emmanuel, Le Cam Laurent, Linares Laetitia K
Abstract excerpt
The mouse double minute 2 (MDM2) oncoprotein is recognized as a major negative regulator of the p53 tumor suppressor, but growing evidence indicates that its oncogenic activities extend beyond p53. Here, we show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis. Identification of MDM2 target genes at the...
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