Article

MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis

2024-09-24

Abstract excerpt

The posttranslational modification (PTM) of innate immune sensor proteins by ubiquitin or ubiquitin-like proteins is crucial for regulating antiviral host responses. The cytoplasmic dsRNA receptor melanoma differentiation-associated protein 5 (MDA5) undergoes several PTMs including ISGylation within its first caspase activation and recruitment domain (CARD), which promotes MDA5 signaling. However, the relevance of...

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Literature Corpus work: ceec75c5-c496-511f-b20d-f2f106e20f20
DOI: 10.1101/2024.09.20.614144

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