Article

Seed-competent tau monomer initiates pathology in PS19 tauopathy mice

2022-01-03

Abstract excerpt

Tau aggregation into ordered assemblies causes myriad neurodegenerative tauopathies. We previously reported that tau monomer exists in either inert (M i ) or seed-competent (M s ) conformational ensembles, and that M s encodes strains, which are biologically active, self-propagating assemblies. We have previously isolated M s from tauopathy brains, but it is unknown if disease begins with M s formation follow...

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Identifiers and source

Literature Corpus work: cee79e17-28f8-5793-9985-6842fb881dc1
DOI: 10.1101/2022.01.03.474806

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