Article

Tau seeding without tauopathy

2022-02-06

Abstract excerpt

Neurodegenerative tauopathies such as Alzheimer’s disease (AD) are caused by brain accumulation of tau assemblies. Evidence suggests tau functions as a prion, and cells and animals efficiently propagate unique tau assemblies. This suggests a dedicated cellular replication machinery, with normal physiologic function for tau seeds. Consequently, we hypothesized that healthy control brains would have seeding activity...

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Identifiers and source

Literature Corpus work: 760acbd7-b274-5c5a-9cd4-94a18189aa82
DOI: 10.1101/2022.02.03.479049

Open publication

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