Article

Impaired adipose anabolism in pancreatic cancer cachexia is reversed by HuR inhibition

2024-12-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background:</h4> Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC), and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear. This work aims to define the relative contributions of catabolism and anabolism to adi...

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Literature Corpus work: cecc6f34-ee0a-53f0-ad63-5312a81ec3d1
DOI: 10.1101/2024.12.27.630549

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