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Article

Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.

Journal of cachexia, sarcopenia and muscle - 1 Aug 2022

Zhong Xiaoling, Narasimhan Ashok, Silverman Libbie M, Young Andrew R, Shahda Safi, Liu Sheng, Wan Jun, Liu Yunlong, Koniaris Leonidas G, Zimmers Teresa A

Abstract excerpt

BACKGROUND: Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for cancer cachexia therapy. However, sex-specific manifestations and mechanisms are poorly understood, constraining development of effective treatments. METHODS:...

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Identifiers

PMID: 35510530
DOI: 10.1002/jcsm.12998
PMCID: PMC9397557

Genes

ACVR2B
FSTL1
WFIKKN2

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