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Article

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.

Cancer research - 15 Aug 2017

Zarei Mahsa, Lal Shruti, Parker Seth J, Nevler Avinoam, Vaziri-Gohar Ali, Dukleska Katerina, Mambelli-Lisboa Nicole C, Moffat Cynthia, Blanco Fernando F, Chand Saswati N, Jimbo Masaya, Cozzitorto Joseph A, Jiang Wei, Yeo Charles J, Londin Eric R, Seifert Erin L, Metallo Christian M, Brody Jonathan R, Winter Jordan M

Abstract excerpt

Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdrawal resulted in a 5- to 10-fold protective effect with chemotherapy treatment. PDAC xenografts were less sensitive to gemcitabine in hypoglycemic mice compared with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28652247
DOI: 10.1158/0008-5472.CAN-17-0015
PMCID: PMC5922269

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.PMID 28652247Read ↗

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