Article

Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose <i>de novo</i> lipogenesis

2025-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic cancer patients have the highest rates and most severe forms of cancer cachexia, yet cachexia etiologies remain largely elusive, leading to a lack of effective intervening therapies. Parathyroid hormone-related protein (PTHrP) has been clinically implicated as a putative regulator of cachexia, with serum PTHrP levels correlating with increased weight loss in PDAC patients. Here we sho...

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Literature Corpus work: cd0cf633-a74c-5289-a038-26195803af52
DOI: 10.1101/2025.06.03.657464

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