Article

Combined AMPK activation and ghrelin ameliorate cancer cachexia through complementary effects on energy homeostasis, inflammation, and wasting

2026-06-24

Abstract excerpt

<h4>Background</h4> Cancer-associated cachexia is characterized by progressive loss of skeletal muscle and adipose tissue driven by systemic inflammation and metabolic dysregulation. AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, but its role in cachexia and its therapeutic potential remains incompletely defined. We investigated AMPK signaling during cachexia and whether pharmac...

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Literature Corpus work: efa18dad-a2e1-5d60-be75-fa7dfb72c00b
DOI: 10.64898/2026.06.23.733859

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