Article

Reinvigoration of translational activity in dysfunctional T cells initiates the early intratumoral response to PD-1 blockade

2025-09-27

Abstract excerpt

T cells are key effectors of antitumor responses elicited by PD-1 blockade. However, it remains elusive by which mechanism(s) PD-1 blockade initiates T cell-driven antitumor immunity in cancer tissues. Here, we dissect early T cell reactivation upon anti-PD-1 in patient-derived tumor fragments. Using bispecific antibodies to target anti-PD-1 to individual T cell subsets, we demonstrate that intratumoral CD8 + and...

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Literature Corpus work: cec7dcae-88c1-5b53-be99-c53c75e37953
DOI: 10.1101/2025.09.24.676875

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