Article

Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-reactive CD8 T cells found in cancer patients are frequently dysfunctional, unable to halt tumor growth. Adoptive T cell transfer (ACT), the administration of large numbers of in vitro -generated cytolytic tumor-reactive CD8 T cells, is an important cancer immune therapy being pursued. However, a limitation of ACT is that transferred CD8 T cells often rapidly lose effector function, and d...

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Literature Corpus work: 78185cf9-4665-55fd-a11c-965798ac6a84
DOI: 10.1101/2023.07.03.547423

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