Article

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours

2025-07-23

Abstract excerpt

CD8 + T cells are a key weapon in the therapeutic armamentarium against cancer. While CD8 + CD103 + T cells with a tissue-resident memory T (T RM ) cell phenotype have been favourably correlated with patient prognoses 1–6 , the tumour microenvironment also contains dysfunctional exhausted T (T EX ) cells that exhibit a myriad of T RM -like features, leading to conflation of these two populations. Here, we d...

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Literature Corpus work: 0b0740df-f767-5cf2-9cac-6eba40b4c4ca
DOI: 10.1101/2025.07.23.666465

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