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Cell Identity and Spatial Distribution of PD‐1/PD‐L1 Blockade Responders

9 Sept 2024

Abstract excerpt

Abstract The programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) axis inhibits T cell activity, impairing anti‐tumor immunity. Blocking this axis with therapeutic antibodies is one of the most promising anti‐tumor immunotherapies. It has long been recognized that PD‐1/PD‐L1 blockade reinvigorates exhausted T (TEX) cells already present in the tumor microenvironment (TME). However, recent advancements in...

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PMID: 39248327
DOI: 10.1002/advs.202400702

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