Article

Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas

1995-10-01

Abstract excerpt

The hereditary multiple endocrine neoplasia syndromes types 2A and B (MEN 2A and B) were recently linked to germline mutations in the RET proto-oncogene, altering one of five cysteine residues in exon 10 or 11 (MEN 2A), or substituting a methionine for a threonine at codon 918 in exon 16 (MEN 2B).The latter mutation also occurs somatically in some sporadic medullary thyroid carcinomas (MTC), and has in a previous...

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Literature Corpus work: cec17da5-71c0-577d-8c9c-cc2169b335ca
DOI: 10.1210/jc.80.10.3088

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