Article
A single missense mutation in codon 918 of the RET proto-oncogene in sporadic medullary thyroid carcinomas.
Endocrine journal - 1 Apr 1995
Maeda S, Namba H, Takamura N, Tanigawa K, Takahashi M, Noguchi S, Nagataki S, Kanematsu T, Yamashita S
Abstract excerpt
The RET proto-oncogene is expressed in human medullary thyroid carcinoma and pheochromocytoma. Recently germline mutations of the RET proto-oncogene were reported in four syndromes (MEN 2A, MEN 2B, familial medullary thyroid carcinoma and Hirschprung's disease) and somatic mutation was also found...
Topics
- Base Sequence
- Carcinoma, Medullary
- Codon
- DNA, Neoplasm
- Drosophila Proteins
- Exons
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ret