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Article

Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.

Genes, chromosomes & cancer - 1 Mar 1995

Eng C, Mulligan L M, Smith D P, Healey C S, Frilling A, Raue F, Neumann H P, Pfragner R, Behmel A, Lorenzo M J

Abstract excerpt

Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and 11 in the extracellular domain of the RET protooncogene. In MEN 2B, germline mutations occur in codon 918 (exon 16) within the catalytic core of the tyrosine kinase domain. To...

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Source

Identifiers

PMID: 7536460
DOI: 10.1002/gcc.2870120308

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.PMID 7536460Read ↗

Germline and somatic mutations of the RET proto-oncogene in apparently sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

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Somatic mutations in RET exons 12 and 15 in sporadic medullary thyroid carcinomas: different spectrum of mutations in sporadic type from hereditary type.Semantic proximity Read ↗

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s.Semantic proximity Read ↗

Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomasSemantic proximity Read ↗

Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

RET protooncogene mutations in patients with apparently sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Three novel mutations in the RET proto-oncogene.Semantic proximity Read ↗

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Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

No correlation between RET immunostaining and the codon 918 mutation in sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Low frequency of germline mutations in the RET proto‐oncogene in patients with apparently sporadic medullary thyroid carcinomaSemantic proximity Read ↗

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