Article
Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.
Genes, chromosomes & cancer - 1 Mar 1995
Eng C, Mulligan L M, Smith D P, Healey C S, Frilling A, Raue F, Neumann H P, Pfragner R, Behmel A, Lorenzo M J
Abstract excerpt
Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and 11 in the extracellular domain of the RET protooncogene....
Topics
- Carcinoma, Medullary
- Female
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 2a
- Multiple Endocrine Neoplasia Type 2b
- Mutation
- Proto-Oncogenes
- Thyroid Neoplasms
- Tumor Cells, Cultured