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Article

Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas.

1 Oct 1995

Abstract excerpt

The hereditary multiple endocrine neoplasia syndromes types 2A and B (MEN 2A and B) were recently linked to germline mutations in the RET proto-oncogene, altering one of five cysteine residues in exon 10 or 11 (MEN 2A), or substituting a methionine for a threonine at codon 918 in exon 16 (MEN 2B). The latter mutation also occurs somatically in some sporadic medullary thyroid carcinomas (MTC), and has in a...

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PMID: 7559902
DOI: 10.1210/jcem.80.10.7559902

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Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomas.PMID 7559902Read ↗

Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomasSemantic proximity Read ↗

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Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

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Germline and somatic mutations of the RET proto-oncogene in apparently sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Somatic mutations in the RET protooncogene in Japanese and Chinese sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Polymorphisms in the RET proto-oncogene and the phenotypic presentation of familial medullary thyroid carcinoma.Semantic proximity Read ↗

A single missense mutation in codon 918 of the RET proto-oncogene in sporadic medullary thyroid carcinomas.Semantic proximity Read ↗

Three novel mutations in the RET proto-oncogene.Semantic proximity Read ↗

RET proto-oncogene mutations are restricted to codon 634 and 618 in Korean families with multiple endocrine neoplasia 2A.Semantic proximity Read ↗

RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.Semantic proximity Read ↗

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