Article
RET proto-oncogene mutations are restricted to codon 634 and 618 in Korean families with multiple endocrine neoplasia 2A.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2004
Chung Yun Jae, Kim Hyung-Hoon, Kim Hyun-Jin, Min Yong-Ki, Lee Myung-Shik, Lee Moon-Kyu, Kim Kwang-Won, Ki Chang-Seok, Kim Jong-Won, Chung Jae Hoon
Abstract excerpt
Identification of the germline mutation in the RET proto-oncogene is important for the diagnosis of hereditary medullary thyroid carcinoma (MTC). Hereditary forms account for approximately 25%-30% of all cases of MTC. The objective of this study was to evaluate the prevalence of the RET mutation and the genotype-phenotype relation in Korean patients with MTC. Genomic DNAs were obtained from 33 patients with MTC...
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