Article

Exploring the alternative lengthening of telomeres through in vitro gene editing and the study of soft tissue sarcomas

2021-01-01

Abstract excerpt

The majority of cancers reactivate telomerase to maintain their telomere length but a minority (10 to 15%) utilize an alternative lengthening of telomeres (ALT) pathway, which involves a specialized form of homologous recombination. The CTC1/STN1/TEN1 (CST) complex plays multiple roles in telomerase-expressing cells but its role in ALT remains poorly studied. As there is more than one mechanism by which telomeres...

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Literature Corpus work: ce88a5e6-1c8d-50c3-952f-3ad8fd6e0dcd
DOI: 10.25392/leicester.data.16558158.v1

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