Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review)

Abstract excerpt

Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α‑thalassemia/mental retardation syndrome X‑linked (ATRX) gene. The ATRX protein belongs to the SWI/SNF family of chromatin remodeling proteins, which are frequently...

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