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Article

A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.

Molecular and cellular biology - 1 Sept 2005

Iyer Shilpa, Chadha Ashley D, McEachern Michael J

Abstract excerpt

Some human cancer cells achieve immortalization by using a recombinational mechanism termed ALT (alternative lengthening of telomeres). A characteristic feature of ALT cells is the presence of extremely long and heterogeneous telomeres. The molecular mechanism triggering and maintaining this pathway is currently unknown. In Kluyveromyces lactis, we have identified a novel allele of the STN1 gene that produces a...

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Source

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Identifiers

PMID: 16135798
DOI: 10.1128/MCB.25.18.8064-8073.2005
PMCID: PMC1234331

Genes

STN1
TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.PMID 16135798Read ↗

Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Semantic proximity Read ↗

Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.Semantic proximity Read ↗

Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype.Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.Semantic proximity Read ↗

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooksSemantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-inSemantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication ProcessesSemantic proximity Read ↗

The first molecular details of ALT in human tumor cellsSemantic proximity Read ↗

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells.Semantic proximity Read ↗

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