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Article

Loss of function of <i>Atrx</i> leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma

2023-11-06

Abstract excerpt

The development of a telomere maintenance mechanism is essential for immortalization in human cancer. While most cancers elongate their telomeres by expression of telomerase, 10-15% of human cancers use a pathway known as alternative lengthening of telomeres (ALT). In this work, we developed a genetically engineered primary mouse model of sarcoma in CAST/EiJ mice which displays multiple molecular features of ALT a...

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Identifiers and source

Literature Corpus work
68917c2d-4688-5e1c-a3bc-88e4d6f7b836
DOI
10.1101/2023.11.06.565874
Open publication

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Loss of function of <i>Atrx</i> leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcomaDOI 10.1101/2023.11.06.565874
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