Article

Prevalence of Alternative Lengthening of Telomeres (ALT) in Pediatric Sarcomas Determined by the Telomeric DNA C-circle Assay

2024-03-11

Abstract excerpt

<h4>Background: </h4> Alternative lengthening of telomeres (ALT) occurs in sarcomas and ALT cancers share common mechanisms of therapy resistance or sensitivity. Telomeric DNA C-circles are self-primed circular telomeric repeats detected with a PCR assay that provide a sensitive and specific biomarker exclusive to ALT cancers. We have previously shown that 23% of high-risk neuroblastomas are of the ALT phenotype....

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Literature Corpus work: a339b5b5-78a4-53e8-a38c-53ccd2a3747b
DOI: 10.22541/au.171015552.20014177/v1

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