Article

SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming

2026-03-25

Abstract excerpt

Chromosomal instability (CIN), arising from errors in chromosome segregation during cell division, is a hallmark of cancer. Whilst CIN can result from several mitotic defects, the mechanisms that initiate CIN to drive tumourigenesis remain incompletely understood. Here, we show that loss of SMAD4 reprograms translation to induce CIN, resulting in tumour formation. Multi-omics analysis of tumourigenesis models driv...

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Literature Corpus work: 99c5a721-e6ac-5b51-8578-f0c18b405a0c
DOI: 10.64898/2026.03.23.712291

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