Article
The transcription factor FLI1 promotes cancer progression by affecting cell cycle regulation.
International journal of cancer - 1 Jul 2020
Miao Beiping, Bauer Andrea S, Hufnagel Katrin, Wu Yenan, Trajkovic-Arsic Marija, Pirona Anna C, Giese Nathalia, Taipale Jussi, Siveke Jens T, Hoheisel Jörg D, Lueong Smiths
Abstract excerpt
Binding of transcription factors to mutated DNA sequences is a likely regulator of cancer progression. Noncoding regulatory mutations such as those on the core promoter of the gene encoding human telomerase reverse transcriptase have been shown to affect gene expression in cancer. Using a protein microarray of 667 transcription factor DNA-binding domains and subsequent functional assays, we looked for...
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