Article

Activation of Chaperon-Mediated Autophagy Via Modulation of Hsp90 Activity Inhibits Tumor Growth Under Hypoxia

2021-10-12

Abstract excerpt

<h4>Background: </h4> Chaperon-mediated autophagy (CMA) is a target specific degradation pathway among autophagic processes. Although CMA plays critical roles in tumor progression in general, the role of CMA in tumor progression under hypoxia is poorly understood. We investigated the role of CMA in hypoxic tumor using a novel Hsp90-mediated modulator of CMA. <h4>Methods: </h4>: We examined whether manassantin A (M...

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Literature Corpus work: ce78e56e-5125-5513-8036-851dee8e7f74
DOI: 10.21203/rs.3.rs-958907/v1

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