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HSP70 Multi-Functionality in Cancer

2 Mar 2020

Abstract excerpt

The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer...

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PMID: 32121660
DOI: 10.3390/cells9030587

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