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Article

The TRiC/CCT Complex at the Crossroads of Metabolism and Hypoxia in GBM: Implications for IDH-Dependent Therapeutic Targeting.

International journal of molecular sciences - 29 Dec 2025

Alberti Giusi, D'Amico Giuseppa, Augello Maria Antonella, Cappello Francesco, Szychlinska Marta Anna, Caruso Bavisotto Celeste, Scalia Federica

Abstract excerpt

Glioblastoma (GBM) is characterized by its unique molecular features, such as self-renewal and tumorigenicity of glioma stem cells that promote resistance, largely resulting in treatment failure. Among the molecular alterations significant to GBM biology and treatment, mutations in isocitrate dehydrogenase (IDH) have assumed particular relevance. IDH-mutant and IDH-wild-type tumors exhibit significantly different...

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Identifiers

PMID: 41516249
DOI: 10.3390/ijms27010373
PMCID: PMC12785705

Genes

EGFR
TCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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