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The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells

1 Sept 2022

Abstract excerpt

Proteasome machinery is a major proteostasis control system in human cells, actively compensated upon its inhibition. To understand this compensation, we compared global protein landscapes upon the proteasome inhibition with carfilzomib, in normal fibroblasts, cells of multiple myeloma, and cancers of lung, colon, and pancreas. Molecular chaperones, autophagy, and endocytosis-related proteins are the most...

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PMID: 36170818
DOI: 10.1016/j.celrep.2022.111428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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