Article
Hypoxia inducible factor-1: a novel target for cancer therapy
15 Sept 2005
Abstract excerpt
Hypoxia develops in the majority of solid tumors due to the inability of the existing vascular system to supply the growing tumor mass with adequate amounts of oxygen. A large body of clinical evidence suggests that intratumoral hypoxia correlates with the elevated aggressive behavior of cancer cells and their resistance to therapy, leading to poor patient prognoses. A heterodimeric transcription factor, hypoxia...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.