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Article

Chaperone-Mediated Autophagy Is Required for Tumor Growth

16 Nov 2011

Abstract excerpt

The cellular process of autophagy (literally "self-eating") is important for maintaining the homeostasis and bioenergetics of mammalian cells. Two of the best-studied mechanisms of autophagy are macroautophagy and chaperone-mediated autophagy (CMA). Changes in macroautophagy activity have been described in cancer cells and in solid tumors, and inhibition of macroautophagy promotes tumorigenesis. Because normal...

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PMID: 22089453
DOI: 10.1126/scitranslmed.3003182

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