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Chaperoning the Cancer: The Proteostatic Functions of the Heat Shock Proteins in Cancer

18 Nov 2016

Abstract excerpt

BACKGROUND: Protein homeostasis (proteostasis) is vital for the survival of cells in physiological and pathological conditions. Particularly, cancer cells are in constant state of cellular stress due to rapid proliferation and decreased quality control in proteosynthesis and therefore, are exceedingly dependent on the homeostasis pathways. Among the complex biological mechanisms regulating proteostasis are the...

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PMID: 27809750
DOI: 10.2174/1574892811666161102125252

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