Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.

Abstract excerpt

Although therapeutically targeting a single signaling pathway that drives tumor development and/or progression has been effective for a number of cancers, in many cases this approach has not been successful. Targeting networks of signaling pathways, instead of isolated pathways, may overcome this problem, which is probably due to the extreme heterogeneity of human tumors. However, the possibility that such...

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