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Article

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

Genes & development - 1 May 2013

Chan Kui-Ming, Fang Dong, Gan Haiyun, Hashizume Rintaro, Yu Chuanhe, Schroeder Mark, Gupta Nalin, Mueller Sabine, James C David, Jenkins Robert, Sarkaria Jann, Zhang Zhiguo

Abstract excerpt

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The median survival of this group of patients after diagnosis is ∼1 yr. Here we show that the levels of H3K27 di- and trimethylation (H3K27me2 and H3K27me3) are reduced globally in H3.3K27M patient samples due to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23603901
DOI: 10.1101/gad.217778.113
PMCID: PMC3656328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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