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Article

Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.

Acta neuropathologica - 1 Dec 2015

Castel David, Philippe Cathy, Calmon Raphaël, Le Dret Ludivine, Truffaux Nathalène, Boddaert Nathalie, Pagès Mélanie, Taylor Kathryn R, Saulnier Patrick, Lacroix Ludovic, Mackay Alan, Jones Chris, Sainte-Rose Christian, Blauwblomme Thomas, Andreiuolo Felipe, Puget Stephanie, Grill Jacques, Varlet Pascale, Debily Marie-Anne

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3-K27M mutant, may comprise more than one biological entity. The aim of the study was to determine the clinical and biological variables that most impact their prognosis. Ninety-one patients with classically...

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PMID: 26399631
DOI: 10.1007/s00401-015-1478-0
PMCID: PMC4654747

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PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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