Article

Functional Studies of MLL-AF4 and a Murinized pSer-variant thereof: MLL-AF4 Impairs the Ribosome Biosynthesis Pathway

2021-07-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (1). In parallel, a group from Japan demonstrated that the pSer domain of the AF4 protein, as well as the pSer domain of the MLL-A...

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Literature Corpus work: ce489afd-ad98-513e-af7b-c8e293b48f09
DOI: 10.21203/rs.3.rs-743930/v1

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