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Article

A MENage à Trois in leukemia.

Cancer cell - 8 Jul 2008

Roudaia Liya, Speck Nancy A

Abstract excerpt

Menin binds to the N terminus of the chromatin-remodeling histone methyltransferase MLL and is essential for the transforming activity of at least several oncogenic MLL fusion proteins. In this issue, Yokoyama and Cleary (2008) show that menin's essential, and perhaps only, contribution to leukemia is to tether a third protein, LEDGF--a chromatin-associated protein implicated in leukemia and several other disease...

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Share to Protein Methyltransferases
Share to Myeloid-Lymphoid Leukemia Protein
Share to Myeloid Progenitor Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Gene Expression Regulation, Leukemic

Share to Histone-Lysine N-Methyltransferase

Share to Histone Methyltransferases

Share to Multiple Endocrine Neoplasia Type 1

Source

Identifiers

PMID: 18598937
DOI: 10.1016/j.ccr.2008.06.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A MENage à Trois in leukemia.PMID 18598937Read ↗

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