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A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

2025-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a stress response mechanism marked by irreversible growth arrest, upregulation of antiapoptotic pathways, loss of cellular function, and remodelling of the cellular secretory profile. In both humans and mice, pancreatic β-cells undergo senescence with age and insulin resistance. Targeted removal of senescent cells in mouse models of diabetes improves glucose homeostasis, d...

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Literature Corpus work
a431a107-d4c9-5f4e-97dd-230cab1e1a36
DOI
10.1101/2025.05.07.648438
Open publication

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A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signalingDOI 10.1101/2025.05.07.648438
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