Neurodevelopmental regression is associated with chromatin, transcriptional and immune dysregulation which can be reversed by HDAC inhibition

Abstract excerpt

<title>Abstract</title> <p> Neurodevelopmental regression in children, including autistic regression, is often associated with inconclusive diagnostic investigations, leaving the underlying pathophysiology poorly understood. We conducted peripheral blood multi-omic profiling in 15 children with neurodevelopmental regression (median age 9 (4-14) years, 60% males, 7 had developmental issues prior to regression), a...

Topics

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• Acetylation
• Cell Line
• Chromatin
• Exome Sequencing
• Frameshift Mutation
• Mutation
• Nervous System Diseases
• Rubinstein-Taybi Syndrome

Identifiers and source

Literature Corpus work

049d05ee-e390-5783-8d41-741e138f9f8c

DOI

10.21203/rs.3.rs-9529401/v1