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Article

Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes.

Scientific reports - 28 May 2021

Mullegama Sureni V, Klein Steven D, Williams Stephen R, Innis Jeffrey W, Probst Frank J, Haldeman-Englert Chad, Martinez-Agosto Julian A, Yang Ying, Tian Yuchen, Elsea Sarah H, Ezashi Toshihiko

Abstract excerpt

MBD5-associated neurodevelopmental disorder (MAND) is an autism spectrum disorder (ASD) characterized by intellectual disability, motor delay, speech impairment and behavioral problems; however, the biological role of methyl-CpG-binding domain 5, MBD5, in neurodevelopment and ASD remains largely undefined. Hence, we created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and...

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Identifiers

PMID: 34050248
DOI: 10.1038/s41598-021-90798-z
PMCID: PMC8163803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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