Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome

Abstract excerpt

<h4>ABSTRACT</h4> Activity-dependent neuroprotective protein (ADNP) syndrome is a rare neurodevelopmental disorder resulting in intellectual disability, developmental delay and autism spectrum disorder (ASD) and is due to mutations in the ADNP gene. Ketamine treatment has emerged as a promising therapeutic option for ADNP syndrome, showing safety and apparent behavioral improvements in a first open label study. Ho...

Topics

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• Child Development Disorders, Pervasive
• DNA Probes
• Language Development Disorders
• Leukocytes, Mononuclear
• Longitudinal Studies
• Oligonucleotide Array Sequence Analysis
• Reference Values
• Transcriptome

Identifiers and source

Literature Corpus work

6a686f85-5fd2-542c-ae20-cdb06302cf1c

DOI

10.1101/2024.01.29.24301949