Article

Localized heterochrony integrates overgrowth potential of oncogenic clones

2022-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Somatic oncogenic mutations are frequent and can occur early during development. The result is the formation of a patchwork of mutant clones. Such mosaicism has been implicated in a broad range of developmental anomalies however their etiology is poorly understood. Patients carrying a common somatic oncogenic mutation in either PIK3CA or AKT1 , can present with disproportionally large digits o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdf10721-65e1-5a8c-b23a-dcf9b13aaebb
DOI: 10.1101/2022.07.15.500211

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Localized heterochrony integrates overgrowth potential of oncogenic clonesDOI 10.1101/2022.07.15.500211Read

Localized heterochrony integrates overgrowth potential of oncogenic clones.Semantic proximity Read

PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulationSemantic proximity Read

Characterization of coordinated growth in macrodactyly caused by somatic mosaic activating mutations in<i>PIK3CA</i>Semantic proximity Read

Decoding G0 somatic mutants through deep phenotyping and mosaic pattern analysis in the zebrafish skeletonSemantic proximity Read

Analysis of neural crest-derived clones reveals novel aspects of facial development.Semantic proximity Read

Zebrafish endochondral growth zones as they relate to human bone size, shape and diseaseSemantic proximity Read

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.Semantic proximity Read

A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.Semantic proximity Read

Conserved signaling pathways underlying heterotopic ossificationSemantic proximity Read

An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters.Semantic proximity Read

PTPRJ Drives Clonal Selection in CEBPA-mutated AMLSemantic proximity Read

Disappearing scales in carps: re-visiting Kirpichnikov's model on the genetics of scale pattern formation.Semantic proximity Read