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PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

2025-12-06

Abstract excerpt

Post-zygotic gain-of-function PIK3CA mutations arising during embryonic development cause disorders collectively known as the PIK3CA -related overgrowth spectrum (PROS). This ranges from minor, localized overgrowth to devastating multi-tissue overgrowth. Disease severity is widely attributed to a combination of PIK3CA genotype, affected cell type, and developmental timing of mutation acquisition. However, in PRO...

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Identifiers and source

Literature Corpus work
0350e785-86c0-5a77-be13-fd8be1cce7e1
DOI
10.64898/2025.12.03.691507
Open publication

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PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulationDOI 10.64898/2025.12.03.691507
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