Article

PTPRJ Drives Clonal Selection in CEBPA-mutated AML

2026-07-08

Abstract excerpt

Transcription factor CEBPA is mutated in 10-15% of acute myeloid leukaemia (AML), a haematopoietic malignancy with high mortality. CEBPA mutations show a distinct pattern, and most patients are biallelic, carrying both an in-frame C-terminal mutation and a frameshift N-terminal mutation on opposing alleles. Rare N-terminal germline cases have 100% penetrance to AML, all with an acquired a C-terminal mutation. Th...

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Literature Corpus work: d0b61990-6252-50ec-bf20-65187ee07f26
DOI: 10.64898/2026.07.07.736996

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