Article
Localized heterochrony integrates overgrowth potential of oncogenic clones.
Disease models & mechanisms - 1 Feb 2023
Blum Nicola, Harris Matthew P
Abstract excerpt
Somatic mutations occur frequently and can arise during embryogenesis, resulting in the formation of a patchwork of mutant clones. Such mosaicism has been implicated in a broad range of developmental anomalies; however, their etiology is poorly understood. Patients carrying a common somatic oncogenic mutation in either PIK3CA or AKT1 can present with disproportionally large digits or limbs. How mutant clones,...
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