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7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer’s disease

2025-01-19

Abstract excerpt

Oxidative stress is a prominent feature of Alzheimer’s disease. Within this context, cholesterol undergoes oxidation, producing the pro-inflammatory product 7-ketocholesterol (7-KC). In this study, we observe elevated levels of 7-KC in the brains of the 3xTg mouse model of AD. To further understand the contribution of 7-KC on the oxidative environment, we developed a method to express a genetically encoded fluores...

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Identifiers and source

Literature Corpus work
cde5391c-ea6b-5cea-9844-050e41d1e02d
DOI
10.1101/2025.01.19.633810
Open publication

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7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer’s diseaseDOI 10.1101/2025.01.19.633810
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