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Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification

20 Oct 2016

Abstract excerpt

Abstract In brains of Alzheimer’s disease (AD), reactive oxygen species (ROS) levels are significantly higher than that of healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Aβ) production, aggregation, plaque formation, microglia/immunological responses, inflammation, and ROS production. In this cycle, ROS species play a central role, and H2O2...

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PMID: 27762326
DOI: 10.1038/srep35613

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